What principle would be violated if research burdens fall disproportionately on a specific demographic group while benefits favor another?

The principle that would be violated in the scenario where research burdens disproportionately impact one demographic group while benefits favor another is justice. Justice in the context of research ethics emphasizes fairness in the distribution of the benefits and burdens of research. It requires that individuals and groups be treated equitably, ensuring that no particular group bears more than its fair share of the risks associated with research while receiving less of the potential benefits.

When burdens and benefits are unevenly distributed, it suggests a failure to uphold the principle of justice, which aims to protect vulnerable populations from exploitation and ensure that all groups have equitable access to the advantages that research may provide. This principle is crucial in ethical research design, as it promotes inclusivity and protects marginalized communities from being unduly affected by research activities.